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Lilly Research Scientist-Medicinal/Computational Chemist in Salem, Oregon

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

For more than 140 years, Eli Lilly has been dedicated to meeting the health care needs of people around the world. We address these needs primarily by developing innovative medicines—investing a percentage of our sales in research and development in the top tier for major pharmaceutical companies. Lilly credits its exceptional employees for its success, and furthermore recognizes that the key to ongoing achievement lies in attracting and retaining the best people. A company rich in heritage, Lilly employs individuals, conducts research and markets products worldwide.

The Medicines Innovation Hub within Lilly Research Laboratories is seeking a highly skilled Drug Discovery Scientist and teammate to join the Computational Chemistry and Informatics group. Do you have strong synthetic organic chemistry skills with deep and extensive working knowledge of modern synthetic chemistry methodologies, experimental work, isolation/purification techniques and structural analysis of synthetic organic molecules? If you also have knowledge in computational techniques to craft molecules we want you on our team! We are an innovative and dynamic company looking to enhance our diverse capabilities in drug discovery. We are committed to continually improving our abilities to make life better for patients around the world.

Lilly is a top Pharmaceutical company with employees dedicated to the patients, families and communities we serve. Come be part of our team!

  • Keep safety as a top priority at any time, striving to maintain a strong safety culture.

  • Formulate hypothesis and design novel small molecules to engage disease modifying targets and contribute critically to the advancement of drug discovery programs from early lead generation to submission of candidate drugs to the clinic.

  • Support de-novo molecular design through computational chemistry, structure-based drug design and ligand-identification technologies to characterize protein-ligand interactions to gain key insights

  • Design optimized lead compounds to improve potency, selectivity, physicochemical properties and DMPK to meet the target product profiles required to invent high-quality medicines.

  • Lead and manage discovery projects across disease areas using CRO and/or in-house and/or resources leading to preclinical candidates for further clinical development. Manage high laboratory synthetic productivity to inform fast-paced SAR iterations through proposal and execution of synthetic routes.

  • Collaborate with colleagues specialized in high-throughput automated synthesis, route optimization and scale-up to maximize the overall efficiency and productivity of the group.

  • Collaborate with scientists across functional areas like pharmacology, translational science, ADME and toxicology to address program needs, increase your business acuity and provide them with Medicinal Chemistry perspectives.

Basic qualifications

  • PhD in Organic Chemistry, Computational Chemistry, Informatics or related field

  • At least 2 years of experience in small molecule organic synthesis and synthetic methodology, either in pharmaceutical industry or postdoctoral experience.

Additional skills/preferences

  • Experience using state-of-the-art Computational Chemistry software and algorithms to craft and optimize small molecule drug targets.

  • Maintain awareness of latest literature of chemical transformations.

  • Scientific creativity and ability to work independently solving problems through careful experimental design, analysis of complex data sets and mechanistic insight.

  • Robust track record of scientific contributions including peer reviewed publications, patents and presentations.

  • Effectively communicate project(s) status, issues, and progress to various management and collaborator groups.

  • Excellent English language oral and written communication skills, ability to engage highly effectively as teammate in a multidisciplinary and international environment.

  • Proficient use of Microsoft Office applications as well as Scifinder, Reaxys or other scientific data tools to identify relevant literature.

  • Strong work ethic. Scientific curiosity. Can do, will do attitude.

  • Medicinal Chemistry and Computational Chemistry expertise in pharmaceutical, biotechnology or academic environments, with solid understanding of the following areas of Drug Discovery will be highly valued:

  • Structure-based drug design.

  • Lead optimization to improve potency, selectivity and properties of compounds.

  • Drug metabolism and pharmacokinetics problem solving.

  • Computational chemistry tools and methods.

  • Biophysical techniques such as X-ray crystallography.

  • Command of scientific informatics and data visualization tools (e.g. StarDrop, TIBCO Spotfire, KNIME) to undertake computationally enabled multi-property optimization approaches.

  • Ability to lead projects and initiatives, coordinating multiple scientific activities and team members simultaneously across various sites.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!